Problem of the Month: May 2026

So You Believe You Know MUPS Tablet Compression?

For those of you manufacturing MUPS tablets: is there something wrong with this tablet?

Notice that on some, but not all tablets, the beads are clustered near the center top of the tablet.

Should you be concerned about it? If you are, what is causing this problem? How do you fix it?

Does it affect the ever so sacred dissolution profile?

The short answer is in almost all cases, especially with Metoprolol, it is harmless.

Next month we’ll look at high sear granulation.

See you in Jakarta later this month.

We’ll learn better how to operate a Fette tablet press!